Synthesis, Characterization and Biological Evaluation of Transition and Inner Transition Metal Complexes of Ligands Derived Schiff Base from 1-phenyl-2, 3-dimethyl-4-(4- iminopentan-2-one)-pyrazole-5-one and 2-aminophenol

The ligand derived from 1-phenyl-2, 3-dimethyl-4-(4-iminopentan-2-one)-pyrazolin-5-one and 2-aminophenol behaved in neutral tetra dentate manner. Its complexes with Ti (III), V (III), Mn (III), Ru (III), MoO (V), MoO2 (VI), and UO2 (VI) were prepared and characterized by elemental analysis, conductivity, magnetic studies and spectral data. Based on these studies octahedral geometry has been proposed for all these complexes. The ligand and selected transition metal complexes have also been evaluated for antimicrobial activity against S. aureus and B. subtilis. From the biological data, we can infer that Schiff base of 4-aminoantipyrin has better antimicrobial activity in comparison to the native one. Also, the antimicrobial activity is highly influenced by the nature of the metal ion. The order of antibacterial activities against S. aureus and B. subtilis are MoO (V) > MoO2 (VI) > UO2 (VI) H” Ru (III) > Mn (III) > V (III) > Ti (III) and Mn (III) > MoO (V) > MoO2 (VI) > Ru (III) > UO2 (VI) > V (III) > Ti (III) respectively.